Venlafaxine Dosage

Venlafaxine dosage is usually 75-225 mg daily once a patient is titrated up to optimal benefit, but it is started slowly to avoid vanlafaxine side effects.

Venlafaxine is a medication that stops reuptake of serotonin and norepinephrine and so is known as a serotonin and norepinephrine reuptake inhibiror(SNRI). By increasing the amount of serotonin and norepinphrine in the fluid between the brain nerve cells if acet to rebalanceg the neurotransmitters to help with depression, social phobia and generalized anxiety disorder. Venlafaxine is also used to help people with anxiety to cope with daily life.

Venlafaxine dosage is usually started with one week of 37.5 mg daily prior to increasing to the lowest typical effective venlafaxine dosage of 75mg daily, but it is halved in people with liver and kidney problems. Like other SSRI and SNRI medications it usually takes several weeks to achieve the desired benefits, so patience is needed when using these drugs. Venlafaxine has a very short drug half-life, so it does not remain in the body for long a time, and most patients use a controlled released capsule to absorb the venlafaxine dosage slowly into the system. The maximum venlafaxine dosage is 225 mg daily, and the effect on norepinephrine reuptake is most noted at the higher doses, primarily doses above 150 mg daily.

Sexual dysfunction, primarily ejaculatory delay in males and orgasm difficulty in women is a very common side effect of venlafaxine. This can be a significant enough problem for some patients that they do not stay on treatment. Venlafaxine is not recommended in pregnancy due to lack of studies showing safety. Venlafaxine also showed increase in suicidal ideation during first few weeks of treatment, and this needs to be watched for by patients and family. Venlafaxine is best not abruptly stopped; it should be tapered before stopping the medication in full to avoid venlafaxine withdrawal syndrome. The short half-life of venlafaxine makes this syndrome more common than with SSRI medications with longer serum half-lives. People with liver and kidney failure should have their dose reduced in most cases, and your physician can help you assess this issue.

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